THE THYROXINE-LIKE ACTIVITY OF COMPOUNDS STRUCTURALLY RELATED TO THYROXINE
نویسندگان
چکیده
منابع مشابه
The thyroxine-like activity of compounds structurally related to thyroxine.
In the course of a search for compounds which might prove to be competitive inhibitors of thyroxine in its action on the peripheral tissues, we have initiated a study of the relationship between chemical structure and thyroxine-like activity of a number of thyroxine analogues. Early attempts to relate chemical constitution to physiological activity have been summarized by Harington (1, 2) who c...
متن کاملTHE THYROXINE-LIKE ACTIVITY OF COMPOUNDS STRUCTURALLY RELATED TO THYROXINE* BY EARL FRIEDENt
In the course of a search for compounds which might prove to be competitive inhibitors of thyroxine in its action on the peripheral tissues, we have initiated a study of the relationship between chemical structure and thyroxine-like activity of a number of thyroxine analogues. Early attempts to relate chemical constitution to physiological activity have been summarized by Harington (1, 2) who c...
متن کاملCompetitive antagonists of thyroxine and structurally related compounds.
Woolley (1) has prepared a number of ethers of N-acetyl-3,5-diiodotyrosine and found them to interfere with various effects of thyroxine on amphibian larvae. Some of Woolley’s observations were confirmed and extended by Winder and Frieden (2) and by Williams et al. (3). It is the purpose of this report to investigate the competitive nature of several thyroxine inhibitors and to determine the st...
متن کاملCOMPETITIVE ANTAGONISTS OF THYROXINE AND STRUCTURALLY RELATED COMPOUNDS* BY EARL FRIEDENt
Woolley (1) has prepared a number of ethers of N-acetyl-3,5-diiodotyrosine and found them to interfere with various effects of thyroxine on amphibian larvae. Some of Woolley’s observations were confirmed and extended by Winder and Frieden (2) and by Williams et al. (3). It is the purpose of this report to investigate the competitive nature of several thyroxine inhibitors and to determine the st...
متن کاملThe effect of thyroxine and related compounds on oxidative phosphorylation.
The finding that oxidative phosphorylation is uncoupled by nitroand halophenols (l-3) has led a number of investigators (4-10) to examine the effect of a physiological halophenol, thyroxine, on this process. Uncoupling of phosphorylation from respiration has been observed following addition of thyroxine and related compounds to suspensions of mitochondria (4-8) as well as in mitochondria isolat...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1948
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)51012-7